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Voltage-gated Kv1. Studies in mouse models have shown that Kv1. Traditionally, KCNA1 was not believed to be expressed in the heart. However, recent studies have revealed that Kv1. This review recounts the winding history of discovery of KCNA1 gene expression and neurocardiac function from fruit flies to mammals and from brain to heart and looks at some of the salient questions that remain to be answered regarding emerging cardiac roles of Kv1. Voltage-gated potassium Kv channels are important regulators of membrane excitability in the brain and heart, controlling action potential initiation, propagation, shape, and repetitive firing properties in neurons and cardiomyocytes [ 1 , 2 ].

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